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Key Documents

M3318

Sigma-Aldrich

Anti-MiRP1 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-Kcne2, Anti-MinK-related Peptide 1

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

immunohistochemistry: suitable using rat ventricule
western blot: 1:200 using rat heart membranes and CHO transfected cells

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... KCNE2(9992)
mouse ... Kcne2(246133)
rat ... Kcne2(171138)

Immunogen

peptide corresponding to amino acid residues 88-107 of rat MiRP1. This epitope is highly homologous in mouse, human, and rabbit, respectively, 18/20, 16/20, and 15/20 residues identical.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Anthony Lewis et al.
The Journal of biological chemistry, 279(9), 7884-7892 (2003-12-18)
High frequency firing in mammalian neurons requires ultra-rapid delayed rectifier potassium currents generated by homomeric or heteromeric assemblies of Kv3.1 and Kv3.2 potassium channel alpha subunits. Kv3.1 alpha subunits can also form slower activating channels by coassembling with MinK-related peptide
Wenjuan Liu et al.
Journal of molecular and cellular cardiology, 72, 208-218 (2014-04-01)
KCNE2 plays an important role in maintaining cardiac electrical stability. Mutations in KCNE2 have been linked to long-QT syndrome (LQT6) and atrial fibrillation/short QT syndrome. It has been suggested that KCNE2 has the most promiscuity of function which can interact
Shawn M Lamothe et al.
The Journal of biological chemistry, 291(39), 20387-20401 (2016-08-10)
The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (IKr), which is important for cardiac repolarization. Dysfunction of hERG causes long QT syndrome and sudden death, which occur in patients with cardiac

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