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M3142

Sigma-Aldrich

Meperidine hydrochloride

Synonym(s):

1-Methyl-4-phenylpiperidine-4-carboxylic acid ethyl ester hydrochloride, Pethidine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H21NO2 · HCl
CAS Number:
50-13-5
Molecular Weight:
283.79
EC Number:
200-013-3
MDL number:
MFCD00058210
UNSPSC Code:
41116107
PubChem Substance ID:
24896799
NACRES:
NA.77

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

originator

Sanofi Aventis

SMILES string

Cl[H].CCOC(=O)C1(CCN(C)CC1)c2ccccc2

InChI

1S/C15H21NO2.ClH/c1-3-18-14(17)15(9-11-16(2)12-10-15)13-7-5-4-6-8-13;/h4-8H,3,9-12H2,1-2H3;1H

InChI key

WCNLCIJMFAJCPX-UHFFFAOYSA-N

Gene Information

human ... OPRM1(4988)

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Biochem/physiol Actions

Phenylpiperidine analgesic; sedative; μ opioid receptor agonist with greater κ opioid receptor agonist activity than morphine.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H336

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B C Yoburn et al.
Pharmacology, biochemistry, and behavior, 51(2-3), 535-539 (1995-06-01)
The effect of chronic opioid antagonist treatment on the analgesic potency of six opioid agonists was compared to changes in opioid receptor density and the selectivity of each agonist for mu (DAMGO), delta (DPDPE) and kappa (U69,593) opioid receptors. Mice
S E Abram et al.
Anesthesiology, 87(1), 127-134 (1997-07-01)
One measure of an opioid's efficacy is its ability to retain its analgesic effect as the intensity of a noxious stimulus is increased. A few studies have assessed the ability of either spinal or systemic opioids to produce analgesia using
A Alt et al.
The Journal of pharmacology and experimental therapeutics, 286(1), 282-288 (1998-07-10)
The ability of endogenous opioids to activate G proteins was measured in membranes from C6 rat glioma cells stably expressing a cloned rat mu receptor. Peptides representing each of the three known families of endogenous opioids (enkephalins, endorphins and dynorphins)
Vanessa S Sakalidis et al.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 8(1), 79-85 (2012-08-01)
The impact of cesarean section (CS) birth and pethidine for post-CS epidural analgesia on early breastfeeding behavior is unclear. This study aimed to measure infant sucking and breastfeeding behavior in infants of mothers who delivered by CS (CS group) and
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