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L5412

Sigma-Aldrich

Anti-Lymphotoxin β Receptor antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-LT-βR

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About This Item

MDL number:
MFCD02096841
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

goat

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

flow cytometry: 2.5 μg using 106 cells
western blot: 0.1-0.2 μg/mL

UniProt accession no.

P36941

storage temp.

−20°C

Gene Information

human ... LTBR(4055)

General description

The antibody will recognize recombinant human LT-βR. Applications include in immunoblotting, flow cytometry, and agonist activity.

Immunogen

recombinant human lymphotoxin β receptor extracellular domain expressed in NS0 cells.

Biochem/physiol Actions

Lymphotoxins (LT) alpha and beta are homologs of tumor necrosis factor. These cytokines play important role in the development and function of immune system, immune response and autoimmunity. The signaling mediated by LTβ receptor mediates autoimmune reactions and the development of secondary lymphoid organs.

Physical form

Lyophilized from 0.2 μm filtered solution of phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hugh McDevitt et al.
Arthritis research, 4 Suppl 3, S141-S152 (2002-07-12)
Tumor necrosis factor (TNF)-alpha and lymphotoxin (LT) alpha/beta play multiple roles in the development and function of the immune system. This article focuses on three important aspects of the effects of these cytokines on the immune response and on autoimmunity.
Role of lymphotoxin in experimental models of infectious diseases: potential benefits and risks of a therapeutic inhibition of the lymphotoxin-beta receptor pathway.
Thomas W Spahn et al.
Infection and immunity, 73(11), 7077-7088 (2005-10-22)
H Körner et al.
Immunology and cell biology, 74(5), 465-472 (1996-10-01)
Tumour necrosis factor (TNF) is a highly potent, proinflammatory cytokine with broad-ranging functions from the regulation of endothelial cell adhesion molecules to facilitate entry of leucocytes into tissues, to direct induction of cellular cytotoxicity. This diversity of function potentially attributable
Yu Mikami et al.
PloS one, 9(12), e114791-e114791 (2014-12-17)
Asthma-related mortality has been decreasing due to inhaled corticosteroid use, but severe asthma remains a major clinical problem. One characteristic of severe asthma is resistance to steroid therapy, which is related to neutrophilic inflammation. Recently, the tumor necrosis factor superfamily

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