K3000

Kinetin riboside

proapoptotic anitproliferative plant growth regulator

• Synonym(s): 6-Furfurylaminopurine riboside, N⁶-(2-Furanyl­methyl)adenosine, N⁶-Furfuryladenosine
• Empirical Formula (Hill Notation): C₁₅H₁₇N₅O₅
• CAS Number: 4338-47-0
• Molecular Weight: 347.33
• EC Number: 224-389-3
• MDL number: MFCD00037987
• UNSPSC Code: 12352207
• PubChem Substance ID: 24896224
• NACRES: NA.72

Properties

• Assay: ≥98% (HPLC); ≥98% (TLC)
• form: powder
• solubility: acetic acid: 49.00-51.00 mg/mL, clear, colorless to yellow
• storage temp.: 2-8°C
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4ccco4)ncnc23
• InChI: 1S/C15H17N5O5/c21-5-9-11(22)12(23)15(25-9)20-7-19-10-13(17-6-18-14(10)20)16-4-8-2-1-3-24-8/h1-3,6-7,9,11-12,15,21-23H,4-5H2,(H,16,17,18)/t9-,11-,12-,15-/m1/s1
• InChI key: CAGLGYNQQSIUGX-SDBHATRESA-N
• Gene Information: rat ... Adora1(29290) , Adora2a(25369) , Adora3(25370)

Description

General description

Kinetin riboside is a ribosylated form of kinetin. It is a natural cytokinin plant hormone.

Application

Kinetin riboside may be used:

• to study its cytotoxic effects on plant and animal tumor cells
• to investigate its apoptotic effects in both cancer and immortalized cells
• to elucidate its influence on human prostate cell epithelial-mesenchymal transition in vitro

Biochem/physiol Actions

Kinetin riboside exhibits cytotoxic and antiproliferative activities. In addition, it also shows anticancer activity by inducing apoptosis in various types of cancers including myeloid leukemia cells, mouse melanoma B16F-10 cells, and plant tumor cells.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves