H4881

Hydrocortisone 21-hemisuccinate sodium salt

≥90% (HPLC)

• Synonym(s): 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate sodium salt, Cortisol 21-hemisuccinate sodium salt
• Empirical Formula (Hill Notation): C₂₅H₃₃NaO₈
• CAS Number: 125-04-2
• Molecular Weight: 484.51
• EC Number: 204-725-5
• MDL number: MFCD00069472
• UNSPSC Code: 12352209
• PubChem Substance ID: 24895659
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Assay: ≥90% (HPLC)
• form: powder
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(COC(CCC([O-])=O)=O)=O)=C1.[Na+]
• InChI: 1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
• InChI key: HHZQLQREDATOBM-CODXZCKSSA-M
• Gene Information: human ... NR3C1(2908)

Description

Application

Hydrocortisone 21-hemisuccinate sodium salt has been used:

• as a component of the maturation medium for hepatic differentiation
• in the corticosterone (CORT) treatment to study its effect on astrocyte-like neural stem cell proliferation in the area postrema of the adult mouse brain
• in cortisol incubation experiments to study the effect of cortisol on the expression and function of sodium-chloride cotransporter (NCC) in zebrafish embryos

Safety Information

• Pictograms: GHS08
• Signal Word: Warning
• Hazard Statements: H361d
• Precautionary Statements: P201 - P308 + P313
• Hazard Classifications: Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves