F7016

Flumequine

≥97.0% (HPLC)

• Synonym(s): 9-Fluoro-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic acid
• Empirical Formula (Hill Notation): C₁₄H₁₂FNO₃
• CAS Number: 42835-25-6
• Molecular Weight: 261.25
• Beilstein: 490724
• EC Number: 255-962-6
• MDL number: MFCD00079298
• UNSPSC Code: 51102829
• PubChem Substance ID: 24894926
• NACRES: NA.85

Properties

• Assay: ≥97.0% (HPLC)
• form: powder
• color: white to off-white
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria
• Mode of action: DNA synthesis | interferes; enzyme | inhibits
• SMILES string: CC1CCc2cc(F)cc3C(=O)C(=CN1c23)C(O)=O
• InChI: 1S/C14H12FNO3/c1-7-2-3-8-4-9(15)5-10-12(8)16(7)6-11(13(10)17)14(18)19/h4-7H,2-3H2,1H3,(H,18,19)
• InChI key: DPSPPJIUMHPXMA-UHFFFAOYSA-N

Description

General description

Chemical structure: fluoroquinolone

Biochem/physiol Actions

Flumequine inhibits topoisomerases, which are needed for the transcription and replication of bacterial DNA. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited .

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves