Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

B3188

Sigma-Aldrich

BYK204165

≥98% (HPLC)

Synonym(s):

4-(1-methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinolin-1,3-dione

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C15H12N2O2
CAS Number:
1104546-89-5
Molecular Weight:
252.27
MDL number:
MFCD12912397
UNSPSC Code:
12352200
PubChem Substance ID:
329773214
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

yellow

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

Cn1cccc1\C=C2/C(=O)NC(=O)c3ccccc23

InChI

1S/C15H12N2O2/c1-17-8-4-5-10(17)9-13-11-6-2-3-7-12(11)14(18)16-15(13)19/h2-9H,1H3,(H,16,18,19)/b13-9-

InChI key

BTYSIDSTHDDAJW-LCYFTJDESA-N

Gene Information

human ... PARP1(142)
mouse ... PARP1(11545)
rat ... PARP1(25591)

Biochem/physiol Actions

BYK204165 is a potent and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1). It is 100-fold selective for PARP-1 over PARP-2.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
059K4632V
059K46321
059K4632

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Robin M Hallett et al.
Molecular oncology, 10(9), 1461-1472 (2016-09-08)
In the pediatric cancer neuroblastoma (NB), patients are stratified into low, intermediate or high-risk subsets based in part on MYCN amplification status. While MYCN amplification in general predicts unfavorable outcome, no clinical or genomic factors have been identified that predict
Facundo H Prado Spalm et al.
Molecular neurobiology, 56(7), 4760-4777 (2018-11-06)
Ceramide (Cer) has a key role inducing cell death and has been proposed as a messenger in photoreceptor cell death in the retina. Here, we explored the pathways induced by C2-acetylsphingosine (C2-Cer), a cell-permeable Cer, to elicit photoreceptor death. Treating
Erika A Newman et al.
Molecular cancer research : MCR, 13(3), 470-482 (2015-01-08)
In neuroblastoma, MYCN genomic amplification and segmental chromosomal alterations including 1p or 11q loss of heterozygocity and/or 17q gain are associated with progression and poor clinical outcome. Segmental alterations are the strongest predictor of relapse and result from unbalanced translocations

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service