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A0972

Sigma-Aldrich

Apolipoprotein A-II from human plasma

≥95% (SDS-PAGE), buffered aqueous solution

Synonym(s):

Apo A-II

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About This Item

MDL number:
MFCD00132612
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human plasma

Quality Level

200

Assay

≥95% (SDS-PAGE)

form

buffered aqueous solution

mol wt

17.38 kDa

UniProt accession no.

P02652

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... APOA2(336)

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General description

Forms dimers in aqueous solutions with an association constant of 5 × 104 M-1. The association is accompanied by an enhancement of ~35% in α-helical content.

Application

Apo A-II constitutes ~20% of the protein moiety of high density lipoprotein (HDL).

Biochem/physiol Actions

Unlike Apo A-I, Apo A-II possesses no activating properties for lectin-cholesterol acyltransferase (LCAT). Furthermore, it was found that Apo A-II inhibits the activation of LCAT by Apo A-I.

Physical form

Solution in 10 mM ammonium bicarbonate.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effect of disulfide cleavage on the molecular weight of one of the major polypeptides of human serum high density lipoprotein.
A M. Scanu et al.
FEBS letters, 18(2), 305-307 (1971-11-01)
Cécile Voisset et al.
The Journal of biological chemistry, 280(9), 7793-7799 (2005-01-06)
The scavenger receptor class B type I (SR-BI) has recently been shown to interact with hepatitis C virus (HCV) envelope glycoprotein E2, suggesting that it might be involved at some step of HCV entry into host cells. However, due to

Articles

Cholesterol Transport

Since cholesterol is a water-insoluble molecule it must be packaged for transport within the plasma. The particles that package cholesterol, cholesteryl esters, and triglycerides for transport, are called lipoproteins.

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