143R-1

CD43 (SP55) Rabbit Monoclonal Antibody

• UNSPSC Code: 12352200
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: SP55, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (143R-14); vial of 0.5 mL concentrate (143R-15); bottle of 1.0 mL predilute (143R-17); vial of 1.0 mL concentrate (143R-16); bottle of 7.0 mL predilute (143R-18)
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• isotype: IgG1
• control: tonsil
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: membranous
• Gene Information: human ... SPN(6693)

Description

General description

CD43, also called leukosialin, is expressed on the surface of all leukocytes except for some resting B-cells. It appears to function as an anti-adhesion molecule, mediating repulsion amongst leukocytes. CD43 expression in lymphomas is highly correlated with CD5; thus most T-cell malignancies and a group of small lymphocyte B-cell malignancies [CLL/ SLL, mantle cell lymphoma (MCL), prolymphocytic leukemia] are often positive, while follicular lymphoma (FL) is usually negative. Anti-CD43 is less useful as a lineage marker, but is a sensitive indicator of aberrant B-cell populations. From 70 to 90% of T-cell lymphomas are labeled with this antibody. Plasmacytoma/myeloma and mast cell disease are also labeled with this antibody. No reactivity has been observed with reactive B-cells.

Quality

IVD

IVD

IVD

RUO

Linkage

CD43 Positive Control Slides, Product No. 143S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

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Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable