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Key Documents

P4554

Supelco

Proparacaine hydrochloride

analytical standard

Synonym(s):

Proxymetacaine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H26N2O3 · HCl
CAS Number:
Molecular Weight:
330.85
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

Cl.CCCOc1ccc(cc1N)C(=O)OCCN(CC)CC

InChI

1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H

InChI key

BFUUJUGQJUTPAF-UHFFFAOYSA-N

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General description

Proparacaine hydrochloride is a topical ocular anesthetic, which is commonly used in pediatric patients.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Topical ophthalmic anesthetic

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

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Ditipriya R Mukhopadhyay et al.
Journal of cataract and refractive surgery, 37(5), 907-913 (2011-03-23)
To assess the effect of a combination of proparacaine 0.50%-sodium fluorescein 0.25% and ultrasound (US) pachymetry on central and midperipheral corneal thickness. School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom. Case series. Topographic measurements of corneal
Mani Baskaran et al.
Investigative ophthalmology & visual science, 55(11), 7669-7673 (2014-10-23)
To evaluate a novel software capable of automatically grading angle closure on EyeCam angle images in comparison with manual grading of images, with gonioscopy as the reference standard. In this hospital-based, prospective study, subjects underwent gonioscopy by a single observer
Miriam L Conway et al.
Journal of cataract and refractive surgery, 36(2), 268-272 (2010-02-16)
To evaluate blood-flow responses before and after microkeratome application. School of Life and Health Sciences, Aston University, Birmingham, United Kingdom. Hemodynamic responses were measured in eyes of healthy volunteers before and after transient elevation in intraocular pressure (IOP) resulting from
M Mehta et al.
Journal of perinatology : official journal of the California Perinatal Association, 30(11), 731-735 (2010-03-20)
The efficacy of topical anesthesia during retinopathy of prematurity (ROP) screening has been a controversial issue. To determine the efficacy of proparacaine eye drops (0.5%), we compared the Premature Infant Pain Profile (PIPP) scores in 40 preterm infants undergoing ROP
Gregory R Blaha et al.
Retina (Philadelphia, Pa.), 31(3), 535-539 (2010-11-26)
To compare the effectiveness of four different anesthetic methods for intravitreal injection. Twenty-four patients each received four intravitreal injections using each of four types of anesthesia (proparacaine, tetracaine, lidocaine pledget, and subconjunctival injection of lidocaine) in a prospective, masked, randomized

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