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F0253000

Fluoxetine hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride, LY-110,140 hydrochloride, Prozac®

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About This Item

Empirical Formula (Hill Notation):
C17H18F3NO · HCl
CAS Number:
56296-78-7
Molecular Weight:
345.79
MDL number:
MFCD00214288
UNSPSC Code:
41116107
PubChem Substance ID:
329799646
NACRES:
NA.24

grade

pharmaceutical primary standard

manufacturer/tradename

EDQM

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical

format

neat

SMILES string

CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl

InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

InChI key

GIYXAJPCNFJEHY-UHFFFAOYSA-N

Gene Information

human ... SLC6A4(6532)

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General description

Fluoxetine hydrochloride,a selective serotonin reuptake inhibitor, is a potent antidepressant agent.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Selective serotonin reuptake inhibitor; antidepressant.

Packaging

Unit quantity: 250 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Legal Information

Sold under license from Eli Lilly and Company.
Prozac is a registered trademark of Eli Lilly and Co.

related product

Product No.
Description
Pricing

Signal Word

Danger

Hazard Statements

H302,H318,H336,H373,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

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Fluoxetine Related Compound B United States Pharmacopeia (USP) Reference Standard

USP

1279826

Fluoxetine Related Compound B

Serotonin hydrochloride powder

Sigma-Aldrich

H9523

Serotonin hydrochloride

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The termination of serotonin (5-hydroxytryptamine, 5-HT) neurotransmission is regulated by its uptake by the 5-HT transporter (5-HTT), as well as its degradation by monoamine oxidase (MAO)-A. MAO-A deficiency results in a wide set of behavioral alterations, including perseverative behaviors and
Melody V Wu et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(8), 1861-1871 (2014-02-13)
Adult hippocampal neurogenesis is critically implicated in rodent models of stress and anxiety as well as behavioral effects of antidepressants. Whereas similar factors such as psychiatric disorder and antidepressant administration are correlated with hippocampal volume in humans, the relationship between
M D Opal et al.
Molecular psychiatry, 19(10), 1106-1114 (2013-10-30)
Current antidepressants must be administered for several weeks to produce therapeutic effects. We show that selective serotonin 2C (5-HT2C) antagonists exert antidepressant actions with a faster-onset (5 days) than that of current antidepressants (14 days) in mice. Subchronic (5 days)
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