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(+)-Isocorydine hydrochloride

analytical standard

Synonym(s):

11-Hydroxy-1,2,10-trimethoxyaporphine, Isocorydine hydrochloride, Luteanine

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About This Item

Empirical Formula (Hill Notation):
C20H23NO4 · HCl
CAS Number:
Molecular Weight:
377.86
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥98.0% (HPLC)

optical activity

[α]/D 180±10°, c = 0.1 in methanol

shelf life

limited shelf life, expiry date on the label

impurities

≤5.0% water

mp

215-218 °C (dec.) (lit.)

application(s)

food and beverages

format

neat

SMILES string

OC1=C2C(C[C@@]3([H])C4=C2C(OC)=C(OC)C=C4CCN3C)=CC=C1OC.Cl

InChI

1S/C20H23NO4.ClH/c1-21-8-7-12-10-15(24-3)20(25-4)18-16(12)13(21)9-11-5-6-14(23-2)19(22)17(11)18;/h5-6,10,13,22H,7-9H2,1-4H3;1H/t13-;/m0./s1

InChI key

ZWSKLEMBDRWSNZ-ZOWNYOTGSA-N

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General description

(+)-Isocorydine is classified under the family of aporphine alkaloids, which are ubiquitously found in various plants. This natural tetrahydroisoquinoline alkaloid is most commonly present in species belonging to the Papaveraceae, Menispermaceae, and Annonaceae families.

Application

(+)-Isocorydine hydrochloride may be used as a precursor for the preparation of (+)-isocorydine, which in turn can be used as an analytical standard for the determination of the analyte in biological samples, and roots and aerial parts of Cryptocarya alba tree species by liquid chromatography based techniques.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Design, synthesis, and anticancer properties of isocorydine derivatives
Yan Q, et al.
Bioorganic & Medicinal Chemistry, 25(24), 6542-6553 (2017)
Changchuan Guo et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(5), 466-476 (2012-02-23)
A rapid and sensitive method for the determination of isocorydine in rat plasma and tissues was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The biological samples were processed by extracting with diethyl ether-dichloromethane (3:2, v/v) and tetrahydropulmatine was used as

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