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Supelco

Ceftiofur

VETRANAL®, analytical standard

Synonym(s):

3-[(2-Furylcarbonyl)thio]methyl]-7-[2-(2-amino-4-thiazolyl)-2-(methoxyiminoacetamido)-3-cephem-4-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C19H17N5O7S3
CAS Number:
80370-57-6
Molecular Weight:
523.56
MDL number:
MFCD00864953
UNSPSC Code:
41116107
PubChem Substance ID:
329754745
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

CO\N=C(/C(=O)N[C@H]1C2SCC(CSC(=O)c3ccco3)=C(N2C1=O)C(O)=O)c4csc(N)n4

InChI

1S/C19H17N5O7S3/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28)/b23-11-/t12-,16?/m1/s1

InChI key

ZBHXIWJRIFEVQY-FITYNHDMSA-N

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General description

Ceftiofur is a third-generation cephalosporin antibiotic, which is commonly used in veterinary medicine for the treatment of respiratory diseases and bacterial infections in farm animals.

Application

Ceftiofur has been used as an analytical reference standard for the determination of the analyte in:
  • Milk samples using receptor binding assays such as Betastar Combo, SNAP, and Twinsensor tests.
  • Environmental water samples using capillary electrophoresis.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCD2522
BCBS8768V
BCBS8758V
SZBF222XV
SZBA174XV

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Fabian M Kausche et al.
Veterinary therapeutics : research in applied veterinary medicine, 4(1), 83-93 (2003-05-21)
Seven well-controlled studies conducted under multiple management conditions demonstrated that ceftiofur, a late-generation veterinary parenteral cephalosporin, is effective for the treatment of bovine foot rot in beef and dairy cattle. Two preliminary dosage titration studies using a challenge model compared
Determination of ceftiofur and its metabolite desfuroylceftiofur in bovine serum and milk by ion-paired liquid chromatography.
Tyczkowska LK, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 614(1), 123-134 (1993)
Alessio Lorusso et al.
The Journal of general virology, 95(Pt 12), 2618-2626 (2014-08-17)
Interactions between the viral surface glycoprotein haemagglutinin (HA) and the corresponding receptors on host cells is one important aspect of influenza virus infection. Mutations in HA have been described to affect pathogenicity, antigenicity and the transmission of influenza viruses. Here
Anton Kaufmann et al.
Rapid communications in mass spectrometry : RCM, 31(22), 1915-1926 (2017-09-07)
The linear intrascan and interscan dynamic ranges of mass spectrometers are important in metabolome and residue analysis. A large linear dynamic range is mandatory if both low- and high-abundance ions have to be detected and quantitated in heavy matrix samples.
Improving the sensitivity of the determination of ceftiofur by capillary electrophoresis in environmental water samples: In-line solid phase extraction and sample stacking techniques.
Puig P, et al.
Analytica Chimica Acta, 587(2), 208-215 (2007)
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