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00749

Sigma-Aldrich

(R)-4-Benzyloxazolidine-2-thione

≥96.0% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C10H11NOS
CAS Number:
190970-58-2
Molecular Weight:
193.27
MDL number:
MFCD06658222
UNSPSC Code:
12352005
PubChem Substance ID:
329747130
NACRES:
NA.22

Quality Level

100

Assay

≥96.0% (HPLC)

optical purity

enantiomeric excess: ≥98.0% (HPLC)

mp

63-67 °C

functional group

phenyl

SMILES string

S=C1N[C@@H](CO1)Cc2ccccc2

InChI

1S/C10H11NOS/c13-10-11-9(7-12-10)6-8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,11,13)/t9-/m1/s1

InChI key

WJSUXYCBZFLXIK-SECBINFHSA-N

Application

A highly selective and efficient chiral auxiliary which can be directly reduced to its corresponding aldehyde and the chiral auxiliary by reductive cleavage with diisobutylaluminum hydride.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
1193264V
1193264

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Velazquez. F.; Olivo, H. F.
Current Organic Chemistry, 6, 303-303 (2002)
M T Crimmins et al.
Organic letters, 2(6), 775-777 (2001-02-07)
[formula: see text] Asymmetric aldol additions using chlorotitanium enolates of thiazolidinethione propionates proceed with high diastereoselectivity for the "Evans" or "non-Evans" syn product depending on the nature and amount of the base used. With (-)-sparteine as the base, selectivities of

Articles

Evans-Type Auxiliaries

The asymmetric aldol reaction mediated by chiral auxiliaries is considered to be one of the most important methods for asymmetric C-C bond formation.

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