SCC172

MC38 Murine Colon Adenocarcinoma Cell Line

• Synonym(s): MCA38 cell line, adenocarcinoma cell line, colon adenocarcinoma cell line, colon cancer cell line, mouse adenocarcinoma cells, mouse carcinoma cell line, mouse colon 38 cell line, murine carcinoma cell line
• UNSPSC Code: 41106514

Properties

• biological source: mouse
• Quality Level: 100
• packaging: vial of ≥1X10⁶ cells/vial vials
• manufacturer/tradename: Millipore
• technique(s): cell based assay: suitable; cell culture | mammalian: suitable
• shipped in: liquid nitrogen
• storage temp.: −196°C

Description

General description

The most common form of colorectal cancer is adenocarcinoma which is responsible for an estimated 96% of colorectal cancers. Adenocarcinoma affects the glandular epithelial cells in the body. Risk factors include smoking, obesity, high alcohol consumption, poor diet, and other inflammatory bowel morbidities. A significant indication for colorectal cancer is the presence of colon polyps, which can take many years to become cancerous. This makes early screening particularly important for preventing cancer progression.

Adenomas are benign tumor polyps formed from the glandular epithelial cells that progressively develop molecular abnormalities until they eventually become metastatic and invasive cancers. Surgical removal is common for treating pre-malignant adenomas as well as advanced metastatic adenocarcinomas. Survival outlook is determined by disease progression at the time of diagnosis. Patients with metastasized colorectal adenocarcinoma have poor survival outlook, with a 5-year survival rate lower than 10%.

Source
The MC38 cell line was derived from a female C57BL/6 mouse.

References
Bioessays 2015, 37(8): 909-920.

Cancer Res 1975, 35(9): 2434-2439.

Application

• Each vial contains > 1X10⁶ viable cells.
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR Panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for interspecies contamination from human, rat, Chinese hamster, Golden Syrian hamster, and nonhuman primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
• Cells are negative for mycoplasma contamination.

Features and Benefits

MC38 is relevant to the continued need to analyze colorectal adenocarcinoma progression, elucidating molecular alterations present in adenocarcinomas and how these mutations drive tumor progression. MC38 is an established and well-characterized model for colorectal cancer, exhibiting rapid growth and expressing colon markers claudin-1 and SATB. The MC38 cell line enables the study of genomic and epigenomic factors to identify colorectal adenocarcinoma treatment options.

Storage and Stability

MC38 cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@milliporesigma.com.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable