264156-M

Caspase-3 Inhibitor II

InSolution

• Synonym(s): InSolution Caspase-3 Inhibitor II, Z-D(OMe)E(Ome)VD(OMe)-FMK
• Empirical Formula (Hill Notation): C₃₀H₄₁FN₄O₁₂
• Molecular Weight: 668.66
• UNSPSC Code: 12352200

Properties

• form: solution
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: clear very faintly yellow
• storage temp.: −20°C

Description

General description

A potent, cell-permeable, and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.

Biochem/physiol Actions

Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10

Warning

Toxicity: Irritant (B)

Sequence

Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK

Physical form

A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264155) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Analysis Note

single spot by TLC

Other Notes

Nicholson, D.W. 1996. Nat. Biotechnol.14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem.271, 1841.0
Nicholson, D.W., et al. 1995. Nature376, 37.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 188.6 °F - (refers to pure substance)
• Flash Point(C): 87 °C - (refers to pure substance)