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700121P

Avanti

sitostanol

β-sitostanol, powder

Synonym(s):

stigmastanol; dihydrositosterol; (3β)-stigmastan-3-ol; (3β,5α)-stigmastan-3-ol

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About This Item

Empirical Formula (Hill Notation):
C29H52O
CAS Number:
83-45-4
Molecular Weight:
416.72
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (700121P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 700121P

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C29H52O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h19-27,30H,7-18H2,1-6H3/t20-,21-,22+,23+,24+,25-,26+,27+,28+,29-/m1/s1

InChI key

LGJMUZUPVCAVPU-HRJGVYIJSA-N

General description

It is predominantly present in pine oil.
Sitostanol is a 5α-saturated sitosterol derivative.
Sitostanol is a plant stanol and a hydrogenated form of sitosterol.

Application

Sitostanol is suitable for its use as a component in micelle preparation, used for cell culture and cellular uptake studies. It is also suitable for use in cell culture to study its effect on a T-helper-1 shift in peripheral blood mononuclear cells (PBMCs) from asthma patients.
Sitostanol may be used in the preparation of binary phospholipid for thermodynamic studies and Brewster angle microscopy studies. It may also be used as a standard steroid in gas chromatography-mass spectrometry(GC-MS).

Biochem/physiol Actions

Plant stanols are structurally similar to cholesterol, hence it reduces the plasma level of LDL cholesterol. Sitostanol is known to possess hypolipidemic and antiatherogenic effects.
Sitostanol decreases cholesterol absorption. Its ratio with cholesterol is implicated in non-alcoholic fatty liver disease (NAFLD). The ratio also correlates with liver steatosis and inflammation. Sitostanol induces interferon γ production and T-helper response in peripheral blood mononuclear cells (PBMC) in asthma patients. It is a hypocholestremic agent as it decreases the micellar solubility and absorption of cholesterol.
Sitostanol lowers the intestinal absorption of cholesterol and serum cholesterol.

Packaging

5 mL Amber Glass Screw Cap Vial (700121P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class Code

11 - Combustible Solids

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Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population
Miettinen TA, et al.
The New England Journal of Medicine, 333(20), 1308-1312 (1995)
The influence of plant stanol on phospholipids monolayers-The effect of phospholipid structure
Hkac-Wydro K, et al.
Journal of Colloid and Interface Science, 360(2), 681-689 (2011)
Beneficial effects of sitostanol on the attenuated immune function in asthma patients: results of an in vitro approach
Brull F, et al.
Testing, 7(10), e46895-e46895 (2012)
The essential role of cholesterol metabolism in the intracellular survival of Mycobacterium leprae is not coupled to central carbon metabolism and energy production
Marques MAM, et al.
Journal of Bacteriology, 197(23), 3698-3707 (2015)
2013 IEEE International Conference on Solid Dielectrics (ICSD) IEEE, 131-131 (2006)
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