925136

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine

• Synonym(s): 2-Sulfonylpyridine, Cysteine-reactive electrophile, S_NAr probe
• Empirical Formula (Hill Notation): C₈H₁₀N₂O₃S
• CAS Number: 2429964-95-2
• Molecular Weight: 214.24
• NACRES: NA.22

Properties

• reaction suitability: reagent type: chemical modification reagent
• Quality Level: 100
• storage temp.: 2-8°C

Description

Application

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine is a sulfoxide-containing fragment for covalent ligand discovery via cysteine labeling as demonstrated by Zamboldo and coworkers. Fragment electrophiles are useful in chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins.

Related useful products may include cysteine fragment KB02 (912131), IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059).

Other Notes

2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable