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462047

Sigma-Aldrich

1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride

97%

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About This Item

Linear Formula:
(CH3)2C6H3OCH2CH(CH3)NH2·HCl
CAS Number:
5370-01-4
Molecular Weight:
215.72
EC Number:
250-825-7
MDL number:
MFCD00216024
UNSPSC Code:
12352100
PubChem Substance ID:
24869930
NACRES:
NA.22

Assay

97%

form

solid

mp

200-203 °C (lit.)

SMILES string

Cl.CC(N)COc1c(C)cccc1C

InChI

1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H

InChI key

NFEIBWMZVIVJLQ-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

General description

1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (Mexiletine) is an anti-arrhythmic agent having local anaesthetic activity. Mexiletine belongs to the triclinc crystal system, with the asymmetric unit containing two independent molecules.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
09708AR

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Sivy J, et al.
Acta Crystallographica Section C, Structural Chemistry, 47(12), 2695-2695 (1991)
Angela K Clouse et al.
Urology, 79(6), 1410-1410 (2012-04-14)
To evaluate the consequence of pharmacologic inhibition of voltage-gated Na(+) channels (Nav) in the conscious rat, based on Nav having been implicated as modulators of rodent urodynamics using knockout as well as antisense oligodeoxynucleotide approaches. The urodynamic response to standard
Tomoyuki Suzuki et al.
Cardiovascular research, 98(1), 136-144 (2013-01-24)
Na(+) channel blockers are often used to treat atrial fibrillation (AF), but may sometimes cause ventricular contractile dysfunction. However, amiodarone, a multi-channel blocker with Na(+) channel block, causes less contractile dysfunction. In this study, we tested the hypothesis that Na(+)
Yuanfeng Gao et al.
Circulation. Arrhythmia and electrophysiology, 6(3), 614-622 (2013-04-13)
Timothy syndrome (TS) is a rare long-QT syndrome caused by CACNA1C mutations G406R in exon 8A (TS1) and G402S/G406R in exon 8 (TS2). Management of TS is a challenge and prognosis is poor. This study aimed to explore the inheritance
Lushan Yu et al.
The Journal of pharmacy and pharmacology, 64(6), 792-801 (2012-05-11)
This study examined the interaction of mexiletine enantiomers with human plasma, human serum albumin (HSA), and human α1-acid glycoprotein (hAGP), and characterized the binding modes of mexiletine enantiomers with hAGP in the molecular level. Enantiomer separation of mexiletine was performed
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