333662

1H-1,2,3-Triazole

97%

• Synonym(s): 2,3-Diazapyrrole, 2H-1,2,3-Triazole, Osotriazole, Pyrrodiazole, Triazacyclopentadiene
• Empirical Formula (Hill Notation): C₂H₃N₃
• CAS Number: 288-36-8
• Molecular Weight: 69.07
• MDL number: MFCD00014490
• UNSPSC Code: 12352100
• PubChem Substance ID: 24860165
• NACRES: NA.22

Properties

• Assay: 97%
• form: liquid
• refractive index: n20/D 1.498 (lit.)
• bp: 203 °C/752 mmHg (lit.)
• mp: 23-25 °C (lit.)
• density: 1.192 g/mL at 25 °C (lit.)
• SMILES string: c1c[nH]nn1
• InChI: 1S/C2H3N3/c1-2-4-5-3-1/h1-2H,(H,3,4,5)
• InChI key: QWENRTYMTSOGBR-UHFFFAOYSA-N

Description

General description

2H-1,2,3-triazole is tautomeric form of 1H-1,2,3-triazole. 1H-1,2,3-triazole effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism.

Application

• Crystalline framework materials: Research on triazole carboxylic acid ligand has demonstrated its application in smart crystalline framework materials, notably for fluorescence sensing and catalytic reduction of p-nitrophenol, illustrating its utility in chemical sensing and environmental applications (Lv et al., 2023).
• PXR receptor modulation: 1H-1,2,3-Triazole-4-carboxamides have been optimized as potent and selective inverse agonists and antagonists of the PXR receptor, providing insights into the design of receptor-specific drugs (Li et al., 2022).
• Large-scale synthesis: The large-scale synthesis of a Notum inhibitor employing a modified Sakai reaction illustrates the importance of 1H-1,2,3-triazole in the production of biochemical reagents, which can be essential in medical research and drug development (Atkinson et al., 2022).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 224.6 °F - closed cup
• Flash Point(C): 107 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves