242705

2-Propanesulfonyl chloride

97%

• Linear Formula: (CH₃)₂CHSO₂Cl
• CAS Number: 10147-37-2
• Molecular Weight: 142.60
• Beilstein: 1747497
• EC Number: 233-415-2
• MDL number: MFCD00007453
• UNSPSC Code: 12352100
• PubChem Substance ID: 24854579
• NACRES: NA.22

Properties

• vapor density: 4 (vs air)
• Quality Level: 100
• vapor pressure: 15.5 mmHg ( 25 °C)
• Assay: 97%
• form: liquid
• autoignition temp.: 865 °F
• refractive index: n20/D 1.453 (lit.)
• bp: 74-75 °C/19 mmHg (lit.)
• density: 1.27 g/mL at 25 °C (lit.)
• SMILES string: CC(C)S(Cl)(=O)=O
• InChI: 1S/C3H7ClO2S/c1-3(2)7(4,5)6/h3H,1-2H3
• InChI key: DRINJBFRTLBHNF-UHFFFAOYSA-N

Description

General description

The solvolysis of 2-propanesulfonyl chloride by an addition-elimination (association-dissociation) pathway was studied.

Application

2-Propanesulfonyl chloride (isopropylsulfonyl chloride) can be used as a reactant to prepare:

• 1-Isopropylsulfonyl-2-amine benzimidazole by reacting with 2-aminobenzimidazole via N-sulfonylation reaction in the presence of a base.
• Bis(isopropylsulfonyl)disulfide, a sulfurizing agent, used to synthesize phosphorothioate oligonucleotide analogs.

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H314
• Precautionary Statements: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Skin Corr. 1B
• Storage Class Code: 8A - Combustible, corrosive hazardous materials
• WGK: WGK 3
• Flash Point(F): 186.8 °F - closed cup
• Flash Point(C): 86 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves