177466
4-Methylcyclohexylamine, mixture of cis and trans
97%
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About This Item
Linear Formula:
CH3C6H10NH2
CAS Number:
Molecular Weight:
113.20
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
97%
form
liquid
refractive index
n20/D 1.4531 (lit.)
bp
151-154 °C (lit.)
density
0.855 g/mL at 25 °C (lit.)
SMILES string
CC1CCC(N)CC1
InChI
1S/C7H15N/c1-6-2-4-7(8)5-3-6/h6-7H,2-5,8H2,1H3
InChI key
KSMVBYPXNKCPAJ-UHFFFAOYSA-N
Related Categories
General description
Trans-4-methylcyclohexylamine is a spermidine synthase inhibitor.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Flam. Liq. 3 - Skin Corr. 1B
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
80.6 °F - closed cup
Flash Point(C)
27 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Masatake Sano et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 845(1), 80-83 (2006-08-26)
An assay for spermidine synthase (SPDS) activity in rat liver has been developed using micellar electrokinetic chromatography (MEKC) with laser-induced fluorescence (LIF) detection to enable the discovery of SPDS inhibitors. The assay was established by estimating the amount of spermidine
Trans-4-methylcyclohexylamine, a potent new inhibitor of spermidine synthase.
A Shirahata et al.
Chemical & pharmaceutical bulletin, 36(8), 3220-3222 (1988-08-01)
Keijiro Samejima
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 126(8), 529-542 (2006-08-02)
This review describes my work in the field of polyamine research for the last 35 years. My research started with developing the improved synthesis of decarboxylated S-adenosylmethionine and then moved to the purification of spermidine synthase from rat prostate. I
TachaZi Plym Forshell et al.
Cancer prevention research (Philadelphia, Pa.), 3(2), 140-147 (2010-01-28)
The oncogenic transcription factor c-Myc (Myc) is frequently overexpressed in human cancers. Myc is known to induce or repress a large set of genes involved in cell growth and proliferation, explaining the selection for mutations in cancer that deregulate Myc
Masaki Kobayashi et al.
Biological & pharmaceutical bulletin, 28(4), 569-573 (2005-04-02)
In rat tissues, a decrease in spermidine, accompanied by an increase in spermine was induced by the oral administration (once daily for either 1 week or 1 month) of trans-4-methylcyclohexylamine (4MCHA), a spermidine synthase inhibitor. This is similar to the
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