TYK2
tyrosine kinase 2
Synonyms:
JTK1
Species:
Human TYK2 (7297), Mouse Tyk2 (54721), Rat Tyk2 (100361294), Zebrafish tyk2 (100536675), chicken TYK2 (430113), dog TYK2 (476714), domestic cat TYK2 (101090171), cow TYK2 (512484), sheep TYK2 (101117248), domestic guinea pig Tyk2 (100715734)
UniProtKB ID:
Gene ID:
- Human(7297) Summary: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
- Mouse(54721) tyrosine kinase 2
- Rat(100361294) tyrosine kinase 2
- Zebrafish(100536675) tyrosine kinase 2
- chicken(430113) tyrosine kinase 2
- dog(476714) tyrosine kinase 2
- domestic cat(101090171) tyrosine kinase 2
- cow(512484) tyrosine kinase 2
- sheep(101117248) tyrosine kinase 2
- domestic guinea pig(100715734) tyrosine kinase 2
- naked mole-rat(101715782) tyrosine kinase 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-Tyk2 (pTyr1054/1055) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
western blot
Anti-TYK2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-TYK2 antibody produced in mouse, clone 6G12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-phospho-TYK2 (pTyr1054) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Monoclonal Anti-TYK2 antibody produced in mouse, clone 6H1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Proteins
Product Number
Description
Species
Tyk2 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE),
Species
human
TYK2 (JTK1), active, GST tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human