UHPLC/MS Analysis of Various Drug Substances on Titan C18
Materiales
Standard
Referencia del producto
Descripción
Precios
Carbamazepine solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®Diazepam solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®Metoprolol tartrate solution
1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®Propranolol hydrochloride solution
1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®CONDITIONS
column
Titan C18, 5 cm x 2.1 mm I.D., 1.9 μm particles (577122-U)
mobile phase
[A] 5 mM ammonium formate; [B] 5 mM ammonium formate in 90:10 (v:v) acetonitrile:water
gradient
30 to 70% B in 3.0 min
flow rate
0.3 mL/min
column temp.
35 °C
detector
MS/MS
injection
3 μL
sample
50 ng/mL in methanol
Descripción
Analysis Note
A Titan C18 column provided rapid, baseline resolution of this set of drug substances. The highest quality LC-MS solvents were used to supply low background interference and low particulate contaminants for robust, trouble-free operation. Cerilliant CRMs provided reliable identification and quantification.
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