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High-Throughput Screens to Discover Small-Molecule Modulators of Ryanodine Receptor Calcium Release Channels.

SLAS discovery : advancing life sciences R & D (2016-10-21)
Robyn T Rebbeck, Maram M Essawy, Florentin R Nitu, Benjamin D Grant, Gregory D Gillispie, David D Thomas, Donald M Bers, Razvan L Cornea
RESUMEN

Using time-resolved fluorescence resonance energy transfer (FRET), we have developed and validated the first high-throughput screening (HTS) method to discover compounds that modulate an intracellular Ca

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Sigma-Aldrich
5,7-Dichloro-8-quinolinol, 99%
Supelco
Cefixime trihydrate, suitable for microbiology, ≥98.0% (HPLC)