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Characterization of microminipigs as an in vivo experimental model for cardiac safety pharmacology.

Journal of pharmacological sciences (2017-03-02)
Suchitra Matsukura, Yuji Nakamura, Xin Cao, Takeshi Wada, Hiroko Izumi-Nakaseko, Kentaro Ando, Hiroshi Yamazaki, Atsushi Sugiyama
RESUMEN

We pharmacologically characterized microminipigs as an in vivo experimental model by assessing cardiovascular effects of pilsicainide, verapamil and E-4031, which can preferentially inhibit cardiac Na

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Pilsicainide hydrochloride, ≥98% (HPLC)