Saltar al contenido
MilliporeSigma

An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2015-10-21)
Kyung Ho Han, Rosana Gonzalez-Quintial, Yingjie Peng, Roberto Baccala, Argyrios N Theofilopoulos, Richard A Lerner
RESUMEN

We have devised a method of using intracellular combinatorial libraries to select antibodies that control cell fates. Many agonist antibodies have been selected with this method, and the process appears to be limited only by the availability of a phenotypic selection system. We demonstrate the utility of this approach to discover agonist antibodies that engage an unanticipated target and regulate macrophage polarization by selective induction of anti-inflammatory M2 macrophages. This antibody was used therapeutically to block autoimmunity in a classic mouse model of spontaneous systemic lupus erythematosus.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
MISSION® esiRNA, targeting human CTSG