Saltar al contenido
MilliporeSigma

Epidemiology. Opposite effects of anthelmintic treatment on microbial infection at individual versus population scales.

Science (New York, N.Y.) (2015-01-13)
Vanessa O Ezenwa, Anna E Jolles
RESUMEN

Parasitic worms modulate host immune responses in ways that affect microbial co-infections. For this reason, anthelmintic therapy may be a potent tool for indirectly controlling microbial pathogens. However, the population-level consequences of this type of intervention on co-infecting microbes are unknown. We evaluated the effects of anthelmintic treatment on bovine tuberculosis (BTB) acquisition, mortality after infection, and pathogen fitness in free-ranging African buffalo. We found that treatment had no effect on the probability of BTB infection, but buffalo survival after infection was ninefold higher among treated individuals. These contrasting effects translated into an approximately eightfold increase in the reproductive number of BTB for anthelmintic-treated compared with untreated buffalo. Our results indicate that anthelmintic treatment can enhance the spread of microbial pathogens in some real-world situations.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
Fenbendazole, ≥98%
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
USP
Fenbendazole, United States Pharmacopeia (USP) Reference Standard
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Supelco
Fenbendazole, VETRANAL®, analytical standard
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Fenbendazole, European Pharmacopoeia (EP) Reference Standard
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad