- Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors.
Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors.
Bioorganic & medicinal chemistry letters (2012-02-22)
Baker Jawabrah Al-Hourani, Sai Kiran Sharma, Mavanur Suresh, Frank Wuest
PMID22341941
RESUMEN
A series of novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors was prepared via treatment of various diaryl amides with tetrachlorosilane/sodium azide. All compounds were tested in cyclooxygenase (COX) assays in vitro to determine COX-1 and COX-2 inhibitory potency and selectivity. Tetrazoles contained a methylsulfonyl or sulfonamide group as COX-2 pharmacophore displayed only low inhibitory potency towards COX-2. Most potent compounds showed IC(50) values of 6 and 7 μM for COX-2. All compounds showed IC(50) values greater 100 μM for COX-1 inhibition.
MATERIALES
Referencia del producto
Marca
Descripción del producto
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad