Formation of benzo[b]fluorenes and the benzo[a]fluorene core of the fluostatins by cyclization of diaryldiynones.

Formation of benzo[b]fluorenes and the benzo[a]fluorene core of the fluostatins by cyclization of diaryldiynones.

Organic letters (2001-06-30)

C Atienza, C Mateo, O de Frutos, A M Echavarren

RESUMEN

[figure: see text] Thermal cyclization of 1-[2-(trimethylsilylethynyl)phenyl]-3-arylpropinones was expected to give benzo[b]fluorenones. However, benzo[a]-fluorenones were also formed as a result of a new rearrangement. These tetracycles possess the core structure of the fluostatins and isoprekinamycin.

MATERIALES

Referencia del producto

Marca

Descripción del producto

275336

Sigma-Aldrich

Benzo[b]fluoranthene, 98%

48490

Supelco

Benzo[b]fluoranthene, analytical standard

12490

Sigma-Aldrich

11H-Benzo[a]fluorene, ≥98.0%

30958

Supelco

Benzo[b]fluoranthene, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland