Saltar al contenido
MilliporeSigma

A ready-to-use integrated in vitro skin corrosion and irritation testing strategy using EpiSkin™ model in China.

Toxicology in vitro : an international journal published in association with BIBRA (2020-01-22)
Yanfeng Liu, Nan Li, Lizao Chen, Nathalie Alépée, Zhenzi Cai
RESUMEN

The need of in vitro alternative methods has been increasing in toxicology research as well as in cosmetic industry in China recently. Following the establishment of China EpiSkin™ skin corrosion and irritation testing methods, both as stand-alone in vitro tests according to Organization for Economic Co-operation and Development (OECD) TG 431 and TG 439, the present study aims to evaluate the use of these two methods within the Integrated Approach on Testing and Assessment (IATA). The IATA, adopted by OECD as Guidance Document 203, provides guidance on the integration of existing and new data in a modular approach for classification and labelling of chemicals according to Globally Harmonized System of classification and labeling of chemicals (GHS) issued by the United Nations (UN). By applying bottom-up and top-down integrated testing strategies to a set of 60 chemicals representing various chemicals classes (organic acid/base/neutral, inorganic acid/base/salt, and surfactant) and physical states (liquid and solid), the results demonstrated that both strategies reached a high overall accuracy of 83.3% to distinguish non-classified, Category 2, Category 1B/1C and Category 1A according to UN GHS, identically. In conclusion, the integration of China EpiSkin™ skin corrosion and irritation testing data into either bottom-up or top-down strategy allows accurate assessment of potential skin hazard of chemicals. It brings a future extension of application of alternative methods and implementation of alternative testing strategies in China.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
Sodium bisulfite solution, purum, ~40%
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
Dipropylene glycol, 99%, mixture of isomers
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
Boron trifluoride dihydrate, 96%
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
cis-13-Docosenoamide
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
Dichloroacetyl chloride, 98%
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
Heptyl butyrate, ≥98%, FG
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
1,9-Decadiene, 97%
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Sigma-Aldrich
Triton N-60
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
General Purpose Viscosity Standard; UKAS ISO/IEC17025 and ISO 17034 certified, viscosity 14.42 mPa.s (25 °C)
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
General Purpose Viscosity Standard; UKAS ISO/IEC17025 and ISO 17034 certified, viscosity 48.59 mPa.s (25 °C)
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
General Purpose Viscosity Standard; UKAS ISO/IEC17025 and ISO 17034 certified, viscosity 71.11 mPa.s (25 °C)
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad