- Gastrin: an acid-releasing, proliferative and immunomodulatory peptide?
Gastrin: an acid-releasing, proliferative and immunomodulatory peptide?
Mini reviews in medicinal chemistry (2010-04-13)
Sara Calatayud, Angeles Alvarez, Víctor M Víctor
PMID20380639
RESUMEN
Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action.