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Merck

SNCA

synuclein, alpha (non A4 component of amyloid precursor)

Sinónimos:
NACP, PARK1, PARK4, PD1
Especie:
Human SNCA (6622), Mouse Snca (20617), Rat Snca (29219), chicken SNCA (395393), Horse SNCA (100053270), domestic cat SNCA (101091694), dog SNCA (478478), cow SNCA (282857), sheep SNCA (100294604), domestic guinea pig Snca (100725375)
ID UniProtKB:
P37840, A8K2A4, Q13701, Q4JHI3, Q6IAU6
ID del gen:
  • Human(6622) Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
  • Mouse(20617) synuclein, alpha
  • Rat(29219) synuclein, alpha (non A4 component of amyloid precursor)
  • chicken(395393) synuclein, alpha (non A4 component of amyloid precursor)
  • Horse(100053270) synuclein, alpha (non A4 component of amyloid precursor)
  • domestic cat(101091694) synuclein, alpha (non A4 component of amyloid precursor)
  • dog(478478) synuclein, alpha (non A4 component of amyloid precursor)
  • cow(282857) synuclein, alpha (non A4 component of amyloid precursor)
  • sheep(100294604) synuclein, alpha (non A4 component of amyloid precursor)
  • domestic guinea pig(100725375) synuclein, alpha (non A4 component of amyloid precursor)
  • naked mole-rat(101700039) synuclein, alpha (non A4 component of amyloid precursor)

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Antibodies

Product Number
Descripción
Reactividad de especies
Aplicación
MABN389
Anti-Aggregated a-Synuclein Antibody, clone 5G4, clone 5G4, from mouse, purified by affinity chromatography,
Reactividad de especies
human
Aplicación
ELISA
immunohistochemistry
western blot
MABN826
Anti-phospho-α-Synuclein (Ser129) Antibody, clone 81A, clone 81A, from mouse,
Reactividad de especies
human, mouse
Aplicación
electron microscopy
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
S5566
Anti-α-Synuclein antibody, Mouse monoclonal, clone Syn211, purified from hybridoma cell culture,
Reactividad de especies
human, zebra finch
Aplicación
immunohistochemistry
immunoprecipitation (IP)
western blot
MABN1817
Anti-α-Synuclein Antibody, clone 2F12, clone 2F12, from mouse,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
36-008
Anticuerpo anti-α-sinucleína, clon Syn211, ascites fluid, clone Syn211, Upstate®,
Reactividad de especies
human
Aplicación
immunohistochemistry
immunoprecipitation (IP)
western blot

Proteins

Product Number
Descripción
Especie
S7820
α-Synuclein human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
Especie
human
AG938
Synuclein, α, recombinant human, ,
Especie
human
575001
α-Synuclein, Human, Recombinant, E. coli, ,
Especie
human
S1071
α-Synuclein A53T human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
Especie
human
AG549
α-synuclein 61-140, human, ,
Especie
human

esiRNA

Product Number
Descripción
Especie
EHU095611
MISSION® esiRNA, targeting human SNCA (1),
Especie
human
EHU140811
MISSION® esiRNA, targeting human SNCA (2),
Especie
human