NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Sinónimos:
GCCR, GCR, GR, GRL
Especie:
Human NR3C1 (2908), Mouse Nr3c1 (14815), Rat Nr3c1 (24413), Zebrafish nr3c1 (553740), chicken NR3C1 (416343), dog NR3C1 (478047), domestic cat NR3C1 (692348), cow NR3C1 (281946), Horse NR3C1 (100061217), domestic cat NR3C1 (101080939) ...Más
ID UniProtKB:
ID del gen:
- Human(2908) Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
- Mouse(14815) nuclear receptor subfamily 3, group C, member 1
- Rat(24413) nuclear receptor subfamily 3, group C, member 1
- Zebrafish(553740) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- chicken(416343) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- dog(478047) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic cat(692348) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- cow(281946) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Horse(100061217) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic cat(101080939) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic guinea pig(100135583) nuclear receptor subfamily 3, group C, member 1
- naked mole-rat(101722101) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Domestic Rabbit(100008890) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- sheep(443412) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Small Molecule - Activator
Small Molecule - Agonist
Referencia del producto
Descripción
Especie
Cortisol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Especie
human
Hydrocortisone 21-hemisuccinate sodium salt, powder, BioReagent, suitable for cell culture,
Especie
human
Small Molecule - Antagonist
Referencia del producto
Descripción
Especie
Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-GR antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-NR3C1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
western blot
Anti-Glucocorticoid Receptor (Ab-2) Mouse mAb (BuGR2), lyophilized, clone BuGR2, Calbiochem®,
Reactividad de especies
guinea pig, mouse, rabbit, rat, sheep
Aplicación
Anti-phospho-Glucocorticoid receptor Antibody, Ser226, from rabbit, purified by affinity chromatography,
Reactividad de especies
human, mouse, rat
Aplicación
western blot
Anti-Glucocorticoid Receptor Antibody, serum, from rabbit,
Reactividad de especies
bovine, canine, feline, horse, human, mouse, nonhuman primates
Aplicación
affinity binding assay
western blot
western blot
Small Molecule - Mixed Agonist/Antagonist
Referencia del producto
Descripción
Especie
Dexametasona, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Especie
mouse, rat, human