LDLR
low density lipoprotein receptor
Sinónimos:
FH, FHC, LDLCQ2
Especie:
Human LDLR (3949), Mouse Ldlr (16835), Rat Ldlr (300438), Zebrafish ldlr (387529), dog LDLR (100683160), chicken LDLR (395103), domestic cat LDLR (101080362), cow LDLR (281276), Domestic Rabbit LDLR (100009086), domestic guinea pig Ldlr (100724238)
ID UniProtKB:
ID del gen:
- Human(3949) Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
- Mouse(16835) low density lipoprotein receptor
- Rat(300438) low density lipoprotein receptor
- Zebrafish(387529) low density lipoprotein receptor
- dog(100683160) low density lipoprotein receptor
- chicken(395103) low density lipoprotein receptor
- domestic cat(101080362) low density lipoprotein receptor
- cow(281276) low density lipoprotein receptor
- Domestic Rabbit(100009086) low density lipoprotein receptor
- domestic guinea pig(100724238) low density lipoprotein receptor
- naked mole-rat(101703463) low density lipoprotein receptor
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ELISA
Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Low Density Lipoprotein Antibody, copper oxidized, serum, Chemicon®,
Reactividad de especies
human
Aplicación
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-LDLR Antibody, clone C7, clone C7, from mouse,
Reactividad de especies
bovine, human
Aplicación
western blot
Anti-LDL Receptor Antibody, clone 2N19, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, rat
Aplicación
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-LDLR antibody produced in rabbit, Ab1, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-LDL Receptor Antibody, clone 2H7.1, clone 2H7.1, from mouse,
Reactividad de especies
human
Aplicación
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot