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HLA-DQA1

major histocompatibility complex, class II, DQ alpha 1

Sinónimos:
CD, CELIAC1, DQ-A1, GSE, HLA-DQA
Especie:
Human HLA-DQA1 (3117)
ID UniProtKB:
P01909, O19630, O19706, P01907, P01908, P04225, P04226, P05536
ID del gen:
  • Human(3117) Summary: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
HPA012315
Anti-HLA-DQA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
MABF3078
Anti-HLA‑DQA1 Antibody, clone SPV-L3, ,
Reactividad de especies
human
Aplicación
blocking
flow cytometry
immunoprecipitation (IP)
SAB5700946
Anti-HLA-DQA1 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
SAB4700650
Monoclonal Anti-HLA-DQ1-DQ3 antibody produced in mouse, clone HL-37, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
flow cytometry
SAB1402223
Monoclonal Anti-HLA-DQA1 antibody produced in mouse, clone 1A3, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
proximity ligation assay
western blot

esiRNA

Referencia del producto
Descripción
Especie
EHU111801
MISSION® esiRNA, targeting human HLA-DQA1,
Especie
human