ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
Sinónimos:
COFS4, RAD10, UV20
Especie:
Human ERCC1 (2067), Mouse Ercc1 (13870), Rat Ercc1 (292673), Zebrafish ercc1 (100001425), cow ERCC1 (615637), domestic cat ERCC1 (101095455), dog ERCC1 (612282), Thale Cress ERCC1 (819685), fruit fly Ercc1 (36654), sheep ERCC1 (101116856) ...Más
ID UniProtKB:
ID del gen:
- Human(2067) Summary: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]
- Mouse(13870) excision repair cross-complementing rodent repair deficiency, complementation group 1
- Rat(292673) excision repair cross-complementing rodent repair deficiency, complementation group 1
- Zebrafish(100001425) excision repair cross-complementing rodent repair deficiency, complementation group 1
- cow(615637) excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
- domestic cat(101095455) excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
- dog(612282) excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
- Thale Cress(819685) DNA excision repair protein ERCC-1
- fruit fly(36654) CG10215 gene product from transcript CG10215-RA
- sheep(101116856) excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
- naked mole-rat(101699727) excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
- domestic guinea pig(100734416) excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Monoclonal Anti-ERCC1 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL1284, purified immunoglobulin, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Anti-ERCC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Monoclonal Anti-ERCC1 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL1249, purified immunoglobulin, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-ERCC1 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse
Aplicación
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-ERCC1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
western blot
western blot