ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Sinónimos:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Especie:
Human ABCB1 (5243), Thale Cress ABCB1 (818265), cow ABCB1 (281585), Horse ABCB1 (100034074), domestic cat ABCB1 (493707), dog ABCB1 (403879), sheep ABCB1 (443367), Domestic Rabbit ABCB1 (100008914), domestic guinea pig Abcb1 (100733532), naked mole-rat Abcb1 (101702843)
ID UniProtKB:
ID del gen:
- Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
- Thale Cress(818265) ABC transporter B family member 1
- cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
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Small Molecule - Agonist
Product Number
Descripción
Especie
Hydrocortisone solution, 50 μM, sterile-filtered, BioXtra, suitable for cell culture,
Especie
human, mouse, rat
Hydrocortisone, γ-irradiated, powder, BioXtra, suitable for cell culture,
Especie
human, mouse, rat
Small Molecule - Antagonist
Antibodies
Product Number
Descripción
Reactividad de especies
Aplicación
Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse, clone F4, ascites fluid,
Reactividad de especies
hamster, human
Aplicación
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
Anti-MDR-1 Antibody, clone 1O12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse
Aplicación
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-MDR1 Antibody, clone JSB-1, culture supernatant, clone JSB-1, Chemicon®,
Reactividad de especies
hamster, human
Aplicación
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57, clone MC57, Chemicon®, from mouse,
Reactividad de especies
human
Aplicación
flow cytometry
immunohistochemistry
immunohistochemistry
Cell Lines
Product Number
Descripción
Especie
Kits
Product Number
Descripción
Especie
Small Molecule - Mixed Agonist/Antagonist
Product Number
Descripción
Especie
Dexametasona, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Especie
mouse, rat, human
Progesterone-Water Soluble, powder, BioReagent, suitable for cell culture,
Especie
mouse, human, rat
Proteins
Product Number
Descripción
Especie
SB-MDR1-Hi5-PREDEASY-ATPase kit, membrane based kit for Human MDR1 ATPase Transport Assays,
Especie
human
esiRNA
Product Number
Descripción
Especie