- The dorsal posterior insula subserves a fundamental role in human pain.
The dorsal posterior insula subserves a fundamental role in human pain.
Nature neuroscience (2015-03-10)
Andrew R Segerdahl, Melvin Mezue, Thomas W Okell, John T Farrar, Irene Tracey
PMID25751532
摘要
Several brain regions have been implicated in human painful experiences, but none have been proven to be specific to pain. We exploited arterial spin-labeling quantitative perfusion imaging and a newly developed procedure to identify a specific role for the dorsal posterior insula (dpIns) in pain. Tract tracing studies in animals identify a similar region as fundamental to nociception, which suggests the dpIns is its human homolog and, as such, a potential therapeutic target.
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辣椒素, European Pharmacopoeia (EP) Reference Standard