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Merck
  • Enantioselective epoxidation of alpha,beta-enones promoted by alpha,alpha-diphenyl-L-prolinol as bifunctional organocatalyst.

Enantioselective epoxidation of alpha,beta-enones promoted by alpha,alpha-diphenyl-L-prolinol as bifunctional organocatalyst.

Organic letters (2005-06-17)
Alessandra Lattanzi
摘要

[reaction: see text] An operationally simple and mild protocol for the catalytic enantioselective epoxidation of alpha,beta-unsaturated ketones has been estabilished using commercially available alpha,alpha-diphenyl-l-prolinol as bifunctional organocatalyst and tert-butyl hydroperoxide (TBHP) as oxidant. The epoxides have been obtained in good yields and with up to 80% ee.

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Sigma-Aldrich
(S)-(-)-α,α-二苯基脯氨醇, 99%
Sigma-Aldrich
(S)-(+)-2-吡咯烷甲醇, 97%