1213103

前列腺素E₂

United States Pharmacopeia (USP) Reference Standard

• 同義詞: (5Z,11α,13E,15S)-11,15-二羟基-9-酮前列-5,13-二烯酸, PGE₂, 地诺前列酮
• 經驗公式（希爾表示法）: C₂₀H₃₂O₅
• CAS號碼: 363-24-6
• 分子量：: 352.47
• Beilstein: 4709356
• MDL號碼: MFCD00077861
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329749635
• NACRES: NA.24

屬性

• 等級: pharmaceutical primary standard
• API 家族: dinoprostone
• 製造商／商標名: USP
• 應用: pharmaceutical (small molecule)
• 格式: neat
• 儲存溫度: −20°C
• SMILES 字串: O[C@@H]1CC([C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O
• InChI: 1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
• InChI 密鑰: XEYBRNLFEZDVAW-ARSRFYASSA-N
• 基因資訊: human ... PTGER1(5731) , PTGER2(5732) , PTGER3(5733) , PTGER4(5734)

描述

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Dinoprostone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

生化／生理作用

生物活性最强的前列腺素。PGE₂ 可诱导宫颈成熟和分娩，介导缓激肽诱导的血管舒张，调节腺苷酸环化酶。 过表达环加氧酶2的肿瘤细胞具有更强的侵袭性、血管生成能力和细胞凋亡抵抗性，这可能是由于PGE₂诱导的血管生成因子表达以及抗凋亡蛋白survivin的稳定化。PGE₂ 对免疫系统具有混合效应。它在体外抑制T细胞活化，表明它是一种免疫抑制剂。然而，在体内，它影响Th17亚群的扩增和T辅助细胞Th1亚群的分化，表明它是一种免疫激活剂。

分析報告

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他說明

Sales restrictions may apply.

安全資訊

• 象形圖: GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H360FD
• 防範說明: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable