Y0002361

Saxagliptin

for system suitability CRS, European Pharmacopoeia (EP) Reference Standard

• 同義詞: Saxagliptin hydrate, (S)-3-Hydroxyadamantylglycine-L-cis-4,5-methanoprolinenitrile hydrate, BMS 477118, BMS 477118-11, BMS-477118, BMS-477118-11, BMS477118, BMS477118-11
• 經驗公式（希爾表示法）: C₁₈H₂₅N₃O₂ · H₂O
• CAS號碼: 945667-22-1
• 分子量：: 333.43
• 分類程式碼代碼: 41116107
• NACRES: NA.24

屬性

• 等級: pharmaceutical primary standard
• API 家族: saxagliptin
• 製造商／商標名: EDQM
• 應用: pharmaceutical
• 儲存溫度: 2-8°C
• SMILES 字串: OC12CC([C@@H](C(N3[C@@H](C[C@]4([C@@]3(C4)[H])[H])C#N)=O)N)(CC(C5)C2)CC5C1.O
• InChI: 1S/C18H25N3O2.H2O/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H2/t10?,11?,12-,13+,14+,15-,17?,18?;/m1./s1
• InChI 密鑰: AFNTWHMDBNQQPX-NHKADLRUSA-N

描述

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Saxagliptin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化／生理作用

Orally active, highly potent & long-acting dipeptidyl peptidase IV (DPP-IV) inhibitor with therapeutic efficacy against type II diabetes in vivo.

Saxagliptin (BMS-477118) is an orally active, highly potent and long-acting dipeptidyl peptidase IV inhibitor (human DPP-IV Ki = 0.9 nM; plasma DDP-IV inhibition = 87% 0.5-4h post 4 μmol/kg po. in normal rats) with therapeutic efficacy against type 2 diabetes in vivo (plasma glucose clearance = 28/43/61% post 0.3/1.0/3.0 μmol/kg po. in Zucker fa/fa rats).

包裝

Unit quantity: 1.082mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

安全資訊

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H317,H334,H361fd,H372
• 防範說明: P202 - P260 - P264 - P280 - P302 + P352 - P308 + P313
• 危險分類: Repr. 2 - Resp. Sens. 1 - Skin Sens. 1 - STOT RE 1
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable