PHL89745

冬凌草甲素

phyproof^® Reference Substance

• 同義詞: 7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one, Isodonol
• 經驗公式（希爾表示法）: C₂₀H₂₈O₆
• CAS號碼: 28957-04-2
• 分子量：: 364.43
• 分類程式碼代碼: 41116107
• NACRES: NA.24

屬性

• 等級: primary reference standard
• 產品線: phyproof^® Reference Substance
• 化驗: ≥98.0% (HPLC)
• 製造商／商標名: PhytoLab
• 應用: food and beverages
• 形式: neat
• SMILES 字串: O1[C@]2([C@]43[C@H]([C@]5([C@H]([C@@H]2O)C(CC[C@@H]5O)(C)C)C1)CC[C@H]([C@H]4O)C(=C)C3=O)O
• InChI: 1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1
• InChI 密鑰: SDHTXBWLVGWJFT-XKCURVIJSA-N

描述

一般說明

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

生化／生理作用

Oridonin has potent anti-tumor activity. Oridonin targets AE (AML1-ETO) oncoprotein. Exposure to oridonin induces apoptosis in AE-bearing leukemic cells through the activation of intrinsic apoptotic pathway and triggering a caspase-3-mediated degradation of AE at D188. The compound also prolonged the lifespan of C57 mice bearing truncated AE-expressing leukemic cells without side effects like suppression of bone marrow or reduction of body weight of animals, and exerted synergic effects while combined with cytosine arabinoside. Additionally, oridonin inhibited tumor growth in nude mice inoculated with t(8;21)-harboring Kasumi-1 cells.

Oridonin has potent anti-tumor activity; targets AE oncoprotein.

法律資訊

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable