BP836

文拉法辛杂质标准品

British Pharmacopoeia (BP) Reference Standard

• 同義詞: 文拉法辛 盐酸盐, (+/-)-1-[2-(二甲基氨基)-1-(4-甲氧基苯基)乙基]环己醇盐酸盐, 盐酸文拉法辛
• 經驗公式（希爾表示法）: C₁₇H₂₇NO₂ · HCl
• CAS號碼: 99300-78-4
• 分子量：: 313.86
• MDL號碼: MFCD03658865
• 分類程式碼代碼: 41116107
• NACRES: NA.24

屬性

• 等級: pharmaceutical primary standard
• API 家族: venlafaxine
• 形狀: solid
• 儲存期限: limited shelf life, expiry date on the label
• 製造商／商標名: BP
• 應用: pharmaceutical; pharmaceutical small molecule
• 形式: mixture
• 儲存溫度: 2-8°C
• SMILES 字串: Cl[H].COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2
• InChI: 1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H
• InChI 密鑰: QYRYFNHXARDNFZ-UHFFFAOYSA-N
• 基因資訊: human ... SLC6A2(6530) , SLC6A4(6532)

描述

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Venlafaxine impurity standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Venlafaxine Tablets

Venlafaxine Prolonged-release Tablets

Venlafaxine Prolonged-release Capsules

生化／生理作用

文拉法辛是一种 5-羟色胺-去甲肾上腺素再摄取抑制剂，其 Ki 值分别为 82 和 2480 nM。它是一种普通的抗抑郁药。

文拉法辛是抗抑郁药。文拉法辛在人中的抗抑郁作用机制与其在中枢神经系统中神经递质活性的增强有关。文拉法辛是神经元 5-羟色胺和去甲肾上腺素再摄取的有效抑制剂，是多巴胺再摄取的弱抑制剂。在体外，文拉法辛对毒蕈碱、组胺能或 α-1 肾上腺素能受体无明显活性。文拉法辛不具有 MAO 抑制剂活性。

包裝

Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他說明

Sales restrictions may apply.

安全資訊

• 象形圖: GHS09
• 危險聲明: H411
• 防範說明: P273 - P391 - P501
• 危險分類: Aquatic Chronic 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable