Z4777

ZK 200775 hydrate

≥98% (HPLC), powder

• 同義詞: Fanapanel, MPQX, [[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-phosphonic acid hydrate
• 經驗公式（希爾表示法）: C₁₄H₁₅F₃N₃O₆P · xH₂O
• CAS號碼: 1255517-78-2
• 分子量：: 409.25 (anhydrous basis)
• MDL號碼: MFCD18452859
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329831618
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: off-white to light brown
• 溶解度: DMSO: ≥20 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: O.OP(O)(=O)CN1C(=O)C(=O)Nc2cc(c(cc12)N3CCOCC3)C(F)(F)F
• InChI: 1S/C14H15F3N3O6P.H2O/c15-14(16,17)8-5-9-11(6-10(8)19-1-3-26-4-2-19)20(7-27(23,24)25)13(22)12(21)18-9;/h5-6H,1-4,7H2,(H,18,21)(H2,23,24,25);1H2
• InChI 密鑰: RYQLMFHPDNKPKY-UHFFFAOYSA-N

描述

一般說明

Z 200775 is a competetive AMPA/kainate receptor antagonist.

ZK 200775 is a selective AMPA/kainite receptor antagonist with very low affinity for NMDA associated binding sites (Ki for CNQX binding site = 32 nM vs. 2.8 uM for DCKA binding site.) ZK 200775 displays superior PK and safety profiles in in vivo studies compared to quinoxalinedione antagonists such as NBQX, showing no effects on motor behavior or cardiac events at efficacious doses in rat. Additionally, unlike other quinoxalinediones, ZK 200775 is water soluble, making this a desirable tool compound for in vivo studies.

特點和優勢

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable