Z3003

Zardaverine

powder, ≥98% (HPLC)

• 同義詞: 6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone
• 經驗公式（希爾表示法）: C₁₂H₁₀F₂N₂O₃
• CAS號碼: 101975-10-4
• 分子量：: 268.22
• MDL號碼: MFCD00867059
• 分類程式碼代碼: 12352202
• PubChem物質ID: 24278784
• NACRES: NA.77

屬性

• 產品名稱: Zardaverine,
• 品質等級: 200
• SMILES 字串: COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2
• InChI: 1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)
• InChI 密鑰: HJMQDJPMQIHLPB-UHFFFAOYSA-N
• 基因資訊: human ... PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE5A(8654) , PDE7A(5150) ; rat ... Pde2a(81743) , Pde4a(25638)

描述

應用

Zardaverine has been used as a phosphodiesterase inhibitor:

• to study its effects on human colonic epithelial cells
• to study its effects on junctional proteins in Sertoli cells
• to study its effects on phosphodiesterase 3 A (PDE3A) expression in various tumor cells

生化／生理作用

Selective inhibitor of phosphodiesterase III/IV (PDE3/4).

Zardaverine is a derivative of pyridazinone. It shows anti-tumor and anti-proliferative activity in varied cell lines. Zardaverine possesses broncho-dilatory activity and exhibits therapeutic effects against asthma.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)