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V4890

Sigma-Aldrich

Vindesine sulfate salt hydrate

≥95% (HPLC)

同義詞:

3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate salt hydrate, Desacetylvinblastine amide sulfate salt hydrate

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About This Item

經驗公式（希爾表示法）:
C43H55N5O7 · H2SO4 · xH2O
CAS號碼:
59917-39-4
分子量：:
852.00 (anhydrous basis)
分類程式碼代碼:
12352200
PubChem物質ID:
329829055
NACRES:
NA.77

品質等級

100

化驗

≥95% (HPLC)

形狀

powder

顏色

off-white to light yellow

溶解度

deionized water: ≥50 mg/mL

起源

Eli Lilly

儲存溫度

−20°C

SMILES 字串

O.OS(O)(=O)=O.CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@H]7[C@](O)([C@H](O)[C@]8(CC)C=CC[N@H]9CC[C@]67[C@H]89)C(N)=O)C1

InChI

1S/C43H55N5O7.H2O4S.H2O/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50;1-5(2,3)4;/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50);(H2,1,2,3,4);1H2/t25-,34+,35-,36-,39+,40-,41-,42+,43+;;/m1../s1

InChI 密鑰

TUDLKTILIBRXNU-RIHOAIHNSA-N

生化／生理作用

Microtubule inhibitor. Vindesine binds to and stabilizes tubulin, thereby preventing tubulin polymerization, preventing mitosis, and arresting cells in metaphase.

特點和優勢

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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Journal of vascular and interventional radiology : JVIR, 22(3), 279-286 (2011-03-01)
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Hematology (Amsterdam, Netherlands), 17 Suppl 1, S93-S97 (2012-04-25)
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Journal of pediatric hematology/oncology, 34(3), 239-241 (2012-01-17)
Peripheral neuropathy is a well-known side effect of vincristine (VCR), a microtubule inhibitor commonly used to treat malignancies. Severe neurological adverse events can occur in patients with Charcot-Marie-Tooth disease (CMT) treated with VCR. Vindesine is also a microtubule inhibitor, which
Kunihiro Tsukasaki
Hematology (Amsterdam, Netherlands), 17 Suppl 1, S32-S35 (2012-04-25)
Adult T-cell leukemia-lymphoma (ATL) was first described in 1977 as a distinct clinico-pathological entity with a suspected viral etiology. Subsequently, a novel RNA retrovirus, human T-cell leukemia/lymphotropic virus type 1 (HTLV-1) was isolated from a cell line established from the
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