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Key Documents

UC441

Sigma-Aldrich

6´,-7´-Dihydroxybergamottin

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About This Item

經驗公式(希爾表示法):
C21H24O6
CAS號碼:
分子量::
372.41
MDL號碼:
分類程式碼代碼:
12161501
PubChem物質ID:
NACRES:
NA.77

形狀

solid

品質等級

顏色

white to light beige

溶解度

ethanol: soluble

儲存溫度

2-8°C

SMILES 字串

C\C(CCC(O)C(C)(C)O)=C/COc1c2C=CC(=O)Oc2cc3occc13

InChI

1S/C21H24O6/c1-13(4-6-18(22)21(2,3)24)8-10-26-20-14-5-7-19(23)27-17(14)12-16-15(20)9-11-25-16/h5,7-9,11-12,18,22,24H,4,6,10H2,1-3H3/b13-8+

InChI 密鑰

IXZUPBUEKFXTSD-MDWZMJQESA-N

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應用

6′,7′-dihydroxybergamottin has been used to study its effect on the inhibition of cytochrome P450 (CYP)-mediated triazolam hydroxylation in dog liver microsomes.

生化/生理作用

CYP3A4 inhibitor.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

準備報告

6′,-7′-Dihydroxybergamottin is soluble in ethanol and can be further diluted with water.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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M J Hanley et al.
Journal of veterinary pharmacology and therapeutics, 33(2), 189-195 (2010-05-07)
Coadministration of grapefruit juice (GFJ) has been proposed to enhance the systemic availability and decrease the required dose of drugs such as cyclosporine that are extensively metabolized in the intestine and liver. Although GFJ inhibits human cytochrome P450 (CYP) 3A

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