U3385

UA62784

≥98% (HPLC)

• 同義詞: 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one
• 經驗公式（希爾表示法）: C₂₃H₁₅NO₃
• CAS號碼: 313367-92-9
• 分子量：: 353.37
• MDL號碼: MFCD00489199
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329827627
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: yellow
• 溶解度: DMSO: >2 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34
• InChI: 1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3
• InChI 密鑰: SVICLWPFAQYZLX-UHFFFAOYSA-N

描述

生化／生理作用

Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.

UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

準備報告

UA62784 is soluble in DMSO at a concentration >2 mg/ml.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable