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Key Documents

T8904

Sigma-Aldrich

噻菌灵

≥99%, powder

同義詞:

2-(4-噻唑基)苯并咪唑

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About This Item

經驗公式(希爾表示法):
C10H7N3S
CAS號碼:
分子量::
201.25
Beilstein:
611403
EC號碼:
MDL號碼:
分類程式碼代碼:
51101500
PubChem物質ID:
NACRES:
NA.85

品質等級

化驗

≥99%

形狀

powder

顏色

white to off-white

溶解度

DMF: soluble 50 mg/mL

抗生素活性譜

fungi
parasites

作用方式

enzyme | inhibits

SMILES 字串

c1ccc2[nH]c(nc2c1)-c3cscn3

InChI

1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)

InChI 密鑰

WJCNZQLZVWNLKY-UHFFFAOYSA-N

基因資訊

human ... CYP2C9(1559)

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一般說明

化学结构式:咪唑

應用

噻苯唑 (TBZ) 是一种广谱抗蠕虫药,用于治疗人体寄生虫感染。用作农业杀菌剂和食品防腐剂 。噻苯唑已被用作重金属螯合解毒剂。临床上用于治疗线虫病、皮肤幼虫移行症、内脏幼虫移行症及旋毛虫病等

生化/生理作用

噻苯唑在线粒体蠕虫特异性酶级别抑制无氧呼吸。在 空肠弯曲菌 幽门螺杆菌 中作为一种醌醇富马酸还原酶 (QFR) 抑制剂,阻断醌氧化为醌。噻苯达唑抑制虫卵和幼虫的产生,并可能抑制随粪便排出的虫卵和幼虫的后续发育 。噻苯达唑的一种生物转化途径是 CYP1A2 催化的羟基化反应,生成 5-羟基噻苯达唑,后者被代谢为葡糖苷酸和硫酸盐结合物

其他說明

将容器密闭保存在干燥和通风良好的地方。在干燥处保存。储存类别 (TRGS 510):非易燃固体

象形圖

Environment

訊號詞

Warning

危險聲明

防範說明

危險分類

Aquatic Acute 1 - Aquatic Chronic 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves


分析證明 (COA)

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Roslyn S Thelingwani et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(6), 1286-1294 (2009-03-21)
Thiabendazole (TBZ) and its major metabolite 5-hydroxythiabendazole (5OH-TBZ) were screened for potential time-dependent inhibition (TDI) against CYP1A2. Screen assays were carried out in the absence and presence of NADPH. TDI was observed with both compounds, with k(inact) and K(I) values
Stuart Dashper et al.
Antimicrobial agents and chemotherapy, 54(3), 1311-1314 (2009-12-30)
Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms
Susanne Rath et al.
Chemosphere, 214, 111-122 (2018-09-28)
Brazil is one of the world's largest producers of animal protein, requiring the large-scale use of veterinary drugs. The administration of antimicrobials and antiparasitics is a common practice. However, there is a lack of information on how these drugs impact
Santosh Soparawalla et al.
The Analyst, 136(21), 4392-4396 (2011-09-06)
We describe a rapid in situ method for detecting agrochemicals on the surface or in the tissue of fruit using a portable mass spectrometer equipped with an ambient ionization source. Two such ionization methods, low temperature plasma (LTP) and paper
Andrew C Kotze et al.
PLoS neglected tropical diseases, 5(6), e1203-e1203 (2011-07-09)
Current efforts to control human soil-transmitted helminths (STHs) involve the periodic mass administration of benzimidazole drugs to school aged children and other at- risk groups. Given that high levels of resistance to these drugs have developed in roundworms of livestock

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